Biology › Section H · Gene expression and its regulation › Topic H.9
Cancer and gene regulation
Cancer is not one disease but a family of gene-control diseases: at every level where a cell regulates its genes — epigenetic marks, transcription factors, RNA stability, translation, protein modification — those controls can break. Tumor suppressors fall silent, proto-oncogenes get stuck on, and checkpoint proteins like cyclin B lose their grip. Understanding the breakage points now drives therapies that target a tumour's specific defects.
In this topic
- Cancer: a disease of altered gene expression
- Checkpoints and the cyclin B case
- Tumor suppressors: the guardians
- Proto-oncogenes: accelerators with a defect
- Epigenetic silencing in cancer cells
- Transcriptional control gone wrong
- After transcription: miRNAs and splice forms
- Worked example: assembling one tumour's path
- Worked example: predicting two epigenetic drugs
- Common mistakes to avoid
- Key takeaways
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