Biology › Section H · Gene expression and its regulation › Topic H.8
Regulation after transcription
A finished transcript is not a finished decision. Eukaryotic cells keep regulating after the RNA is made - choosing which protein a gene yields, how long the message survives, whether it gets translated at all, and how long the protein persists - giving one gene many outputs and one stimulus many rapid responses.
In this topic
- After the transcript, before the protein
- Alternative splicing: one gene, many proteins
- The shelf life of a message
- UTRs and the proteins that read them
- microRNAs and the RISC shredder
- Translation's throttle: eIF-2
- Tagging the protein itself
- Ubiquitin: the demolition flag
- Worked example: predicting miRNA effects
- Worked example: reading the eIF-2 experiment
- Common mistakes to avoid
- Key takeaways
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