Biology › Section I · Biotechnology and genomics › Topic I.2
Mapping and sequencing genomes
Genome maps and DNA sequencing: how genetic linkage, physical distances, and chain-termination chemistry combine to read every base of a species' DNA.
In this topic
- From genes on chromosomes to complete genomes
- Genetic maps come from linkage analysis
- Genetic markers: the landmarks
- Physical maps count nucleotides
- Worked example: ordering three genes from recombination data
- Chain termination: reading a strand base by base
- Whole-genome sequencing: shotgun and pairwise-end strategies
- Worked example: rebuilding a contig from three reads
- Model organisms, annotation, and comparing sequences
- What genome sequences buy us — and what they cost
- Common mistakes to avoid
- Key takeaways
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