Biology › Section G · Chromosomes and DNA › Topic G.5
Replication in prokaryotes and eukaryotes
Unzipping the helix was the easy part to guess. The real process needs a crew of enzymes - one to open the DNA, one to prime it, one to build, one to finish - and eukaryotes add a second problem their circular-chromosomed cousins never face: what to do about the very ends of linear chromosomes.
In this topic
- Where replication starts
- Opening the helix
- The primer problem
- Leading and lagging strands
- Finishing the copy
- Worked example: the impaired fork
- Eukaryotes: same plan, bigger scale
- The end problem: telomeres and telomerase
- Telomeres in aging and cancer
- Worked example: why eukaryotes need 100,000 origins
- Common mistakes to avoid
- Key takeaways
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