Biology › Section H · Gene expression and its regulation › Topic H.6
Epigenetic regulation
Every cell carries the same genes, yet a liver cell is not a neuron. The first layer of the answer is not in the sequence at all - it is in how tightly the DNA is wound. Epigenetics regulates access to genes by tagging histones and DNA, opening some regions and sealing others shut, all without changing a single base.
In this topic
- Around genetics
- Beads on a string
- The histone code: tags and charge
- Methylating the DNA itself
- Open versus closed
- Not mutation, not forever
- X inactivation: a whole chromosome, silenced
- Epigenetics meets medicine
- Worked example: the one-leg experiment
- Worked example: predicting the inactive X
- Common mistakes to avoid
- Key takeaways
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